Proteomic analysis of valproic acid-induced embryotoxicity in cultured post-implantation rat embryos
نویسندگان
چکیده
منابع مشابه
Valproic Acid-Induced Skeletal Defects and Spina Bifida in Rat Fetuses
Purpose: Among antiepileptic drugs, valproic acid (VA) is a well known teratogenic agent. We previously reported that maternal (VA) administration of VA during critical periods of rat pregnancy can produce very rare CNS defect, syringomyelia. The purpose of the present study was whether VA can affect other organs, based on this finding, we studied the teratogenic effects of it on rat developing...
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Purpose: we previously reported that maternal valproic acid (VA) administration during rat pregnancy produced CNS defect ranely, syringomyelia. Furthermore, it seems that administration of valproic acid during critical period of pregnancy may affect on development of other embryonic skeletal portion such as craniofacial region. The goal of our study was to determine whether there is a relations...
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2,4-dichlorophenoxyacetic acid (2,4-D), a plant growth regulator, has been used worldwide as a herbicide. Previously we evaluated the prenatal developmental effects of 2,4-D by feeding it to pregnant rats and found that it is maternally toxic and embryolethal, and it induces urogenital malformations in rat fetuses. In the study presented here, we investigated the effects of pure 2,4-D on rat em...
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The aim of the present study was to examine the effects of scriptaid (SCR), a histone deacetylase inhibitor (HDACi), on the in vitro and in vivo development of Wuzhishan miniature pig somatic cell nuclear transfer (SCNT) embryos. Experiment 1 compared the in vitro developmental competence of nuclear transfer embryos treated with various concentrations of SCR for 24 h. Embryos treated with 250 n...
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ژورنال
عنوان ژورنال: Fundamental Toxicological Sciences
سال: 2017
ISSN: 2189-115X
DOI: 10.2131/fts.4.31